Therapeutic Area | MeSH |
---|---|
nutritional and metabolic diseases | D009750 |
endocrine system diseases | D004700 |
Indication | Ontology | MeSH | ICD-10 |
---|---|---|---|
hypocalcemia | HP_0002901 | D006996 | E83.51 |
hypoparathyroidism | — | D007011 | E20 |
Expiration | Code | ||
---|---|---|---|
parathyroid hormone, Natpara, Takeda Pharmaceuticals U.S.A., Inc. | |||
2122-01-23 | Orphan excl. |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Secondary hyperparathyroidism | D006962 | EFO_1001173 | — | 5 | 7 | 20 | 11 | 15 | 57 |
Osteoporosis | D010024 | HP_0000939 | M81.0 | 10 | 15 | 11 | 5 | 12 | 50 |
Hypoparathyroidism | D007011 | HP_0000829 | E20 | 5 | 8 | 12 | 4 | 19 | 46 |
Primary hyperparathyroidism | D049950 | EFO_0008519 | E21.0 | 3 | 4 | 6 | 1 | 26 | 37 |
Hyperparathyroidism | D006961 | EFO_0008506 | E21.3 | 6 | 3 | 3 | 2 | 18 | 32 |
Vitamin d deficiency | D014808 | EFO_0003762 | E55 | 1 | 2 | 4 | 9 | 13 | 28 |
Chronic renal insufficiency | D051436 | — | N18 | 2 | 3 | 12 | 4 | 6 | 26 |
Parathyroid diseases | D010279 | — | E21.5 | — | 1 | 5 | 1 | 19 | 26 |
Parathyroid neoplasms | D010282 | — | — | 1 | 2 | 4 | 2 | 16 | 25 |
Hypercalcemia | D006934 | HP_0003072 | E83.52 | 1 | 3 | 3 | 2 | 9 | 17 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Postmenopausal osteoporosis | D015663 | EFO_0003854 | — | 4 | 4 | 1 | — | 1 | 9 |
Endocrine system diseases | D004700 | EFO_0001379 | E34.9 | — | 1 | 3 | — | 2 | 6 |
Digeorge syndrome | D004062 | — | D82.1 | 2 | 2 | 1 | — | — | 4 |
Kidney diseases | D007674 | EFO_0003086 | N08 | — | — | 2 | — | 1 | 3 |
Dialysis | D003956 | — | — | — | — | 1 | — | 2 | 3 |
Metabolic bone diseases | D001851 | HP_0000938 | — | — | 1 | 2 | — | 1 | 3 |
Renal insufficiency | D051437 | HP_0000083 | N19 | — | 1 | 1 | — | 2 | 3 |
Hip fractures | D006620 | EFO_0003964 | S72.00 | — | — | 1 | — | 1 | 2 |
Spontaneous abortion | D000022 | EFO_1001255 | O00.1 | — | 1 | 1 | — | — | 1 |
Hyperphosphatemia | D054559 | HP_0002905 | — | — | — | 1 | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Neoplasms | D009369 | — | C80 | 6 | 1 | — | — | 1 | 8 |
Head and neck neoplasms | D006258 | — | — | 1 | 2 | — | — | 2 | 5 |
Lymphoma | D008223 | — | C85.9 | 2 | 1 | — | — | — | 3 |
Kidney transplantation | D016030 | — | — | — | 1 | — | — | 2 | 3 |
Bone diseases | D001847 | — | M89.9 | — | 1 | — | — | 2 | 3 |
Myeloid leukemia acute | D015470 | — | C92.0 | 1 | 1 | — | — | — | 2 |
Vascular calcification | D061205 | — | — | — | 1 | — | — | 1 | 2 |
Osteoporotic fractures | D058866 | — | — | — | 1 | — | — | 1 | 2 |
Psoriasis | D011565 | EFO_0000676 | L40 | 1 | 2 | — | — | — | 2 |
Bone resorption | D001862 | — | — | 1 | 1 | — | — | 1 | 2 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Thyroidectomy | D013965 | — | — | 1 | — | — | — | 9 | 10 |
Healthy volunteers/patients | — | — | — | 7 | — | — | — | 1 | 8 |
Endocrine bone diseases | D001849 | — | — | 2 | — | — | — | 1 | 3 |
Prostatic neoplasms | D011471 | — | C61 | 1 | — | — | — | 1 | 2 |
Breast neoplasms | D001943 | EFO_0003869 | C50 | 2 | — | — | — | — | 2 |
Goiter | D006042 | HP_0000853 | E04.9 | 1 | — | — | — | 1 | 2 |
Familial hypophosphatemic rickets | D053098 | — | — | 1 | — | — | — | — | 1 |
Bone neoplasms | D001859 | EFO_0003820 | D16 | 1 | — | — | — | — | 1 |
Type 2 diabetes mellitus | D003924 | EFO_0001360 | E11 | 1 | — | — | — | — | 1 |
Stem cell transplantation | D033581 | — | — | 1 | — | — | — | — | 1 |
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
---|---|---|---|---|---|---|---|---|---|
Papillary thyroid cancer | D000077273 | — | — | — | — | — | — | 3 | 3 |
Hyperthyroidism | D006980 | — | E05.9 | — | — | — | — | 3 | 3 |
Parathyroidectomy | D016105 | — | — | — | — | — | — | 3 | 3 |
Pseudohypoparathyroidism | D011547 | — | E20.1 | — | — | — | — | 3 | 3 |
Covid-19 | D000086382 | — | U07.1 | — | — | — | — | 2 | 2 |
Multiple organ failure | D009102 | EFO_1001373 | — | — | — | — | — | 2 | 2 |
Drug-related side effects and adverse reactions | D064420 | — | T88.7 | — | — | — | — | 2 | 2 |
Menopause | D008593 | EFO_0003922 | N95 | — | — | — | — | 2 | 2 |
Endocrine gland neoplasms | D004701 | EFO_0003769 | D35 | — | — | — | — | 2 | 2 |
Proteinuria | D011507 | HP_0000093 | R80 | — | — | — | — | 1 | 1 |
Drug common name | Parathyroid hormone |
INN | parathyroid hormone |
Description | Parathyroid hormone (PTH), also called parathormone or parathyrin, is a peptide hormone secreted by the parathyroid glands that regulates the serum calcium concentration through its effects on bone, kidney, and intestine.
|
Classification | Protein |
Drug class | — |
Image (chem structure or protein) | |
Structure (InChI/SMILES or Protein Sequence) | >3FFD:A|Monoclonal antibody, heavy chain, Fab fragment
EVQLVESGGDLVKPGGSLKLSCAASGFTFSSYGMSWIRQTPDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY
LQMSSLKSEDTAMFYCARQTTMTYFAYWGQGTLVTVSAAKTTPPSVYPLAPGSAAQTNSMVTLGCLVKGYFPEPVTVTWN
SGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIEPA
>3FFD:B|Monoclonal antibody, light chain, Fab fragment
QLVLTQSSSASFSLGASAKLTCTLSSQHSTYTIEWYQQQPLKPPKYVMDLKQDGSHSTGDGIPDRFSGSSSGADRYLSIS
NIQPEDEAMYICGVGDTIKEQFVYVFGGGTKVTVLGEPKSTPTLTVFPPSSEELKENKATLVCLISNFSPSGVTVAWKAN
GTPITQGVDTSNPTKEGNKFMASSFLHLTSDQWRSHNSFTCQVTHEGDTVEKSLSPAECL |
PDB | 1BL1, 1BWX, 1BZG, 1ET1, 1FVY, 1HPH, 1HPY, 1HTH, 1M5N, 1ZWA, 1ZWB, 1ZWC, 1ZWD, 1ZWE, 1ZWF, 1ZWG, 2L1X, 3C4M, 3FFD, 3H3G, 3L2J, 4YD8, 4Z8J, 5EMB, 6FJ3, 6NBF, 6NBH, 6NBI, 6XT9, 7F16, 7UZO, 7UZP, 7VVJ, 7VVK, 7VVL, 7VVM, 7VVN, 7VVO, 7Y35, 7Y36, 8BIA, 8BJ0, 8D51, 8D52, 8FLQ, 8FLR, 8FLS, 8FLT, 8FLU, 8GW8, 8HA0, 8HAF, 8HAO, 8JR9, 8T5F |
CAS-ID | — |
RxCUI | — |
ChEMBL ID | CHEMBL2108078 |
ChEBI ID | — |
PubChem CID | — |
DrugBank | — |
UNII ID | N19A0T0E5J (ChemIDplus, GSRS) |